Objectives: To evaluate the combined effect of a lifestyle program focused on low dietary GI and PA on BC recurrence in the context of a MeD.Methods: One hundred and forty-nine women (30-74 yrs) with primary BC, participating in DEDiCa study (NCT02786875), were randomized into one of two treatments: 1) Group A (N= 73) recommendations on a traditional MeD with low GI carbohydrates+ brisk walk of at least 30min per day+ vitamin D supplementation to reach blood levels of 15-OH-D of 60 ng/ml; 2) Group B (N= 76) recommendations on a traditional MeD with whole grains+ avoidance of sedentary behaviour+ vitamin D supplementation (30 ng/ml). Every 3 months we assessed: anthropometric and biochemical parameters, dietary habits by 7 days food records, PA by 7-day step counter and questions. All statistical analysis was performed using SPSS v. 25.0.Results: At 12 months a significant reduction (p< 0 …